NrCAM anticorps (AA 30-845) (PerCP)

N° du produit ABIN6658004

N° du produit (Fournisseur): 200-365-w74

Cet anticorps anti-NrCAM est un anticorps Souris Monoclonal détectant NrCAM dans WB, ELISA et IHC. Adapté pour Souris.

Aperçu rapide pour NrCAM anticorps (AA 30-845) (PerCP) (ABIN6658004)

Antigène: NrCAM (NRCAM) (Neuronal Cell Adhesion Molecule (NRCAM))

Reactivité: Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp NrCAM est conjugé à/à la PerCP

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Clone: S364-51

Détail du produit anti-NrCAM anticorps (PerCP)

Épitope: AA 30-845

N° du produit (Fournisseur): 200-365-w74

Fournisseur: Rockland

Fonction: NrCAM Antibody PerCP

Réactivité croisée (Details): BLAST analysis suggests that it is 96 % identical to rat, 91 % identical to human and ~50 % identical to Neurofascin.

Purification: Anti-NrCAM Antibody was purified from concentrated tissue culture supernate by Protein G chromatography.

Stérilité: Sterile filtered

Immunogène: Anti-NrCAM Antibody was produced by repeated immunization of mice with a fusion protein containing amino acids 30-845 of mouse NrCAM.

Isotype: IgG2a

Information d'application

Indications d'application:

ELISA_Dilution: 1:10,000

Western_Blot_Dilution: 1:1000

Commentaires:

Anti-NrCAM PerCP Conjugated Antibody is suitable for Western Blots and Immunocytochemistry. Expect a band approximately ~160kDa on specific lysates or tissues. Specific conditions for reactivity should be optimized by the end user.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer:

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Stabilizer: 50 % (v/v) Glycerol

Preservative: 0.1 % (w/v) Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

Date de péremption: 12 months

Détails sur NrCAM

Antigène: NrCAM (NRCAM) (Neuronal Cell Adhesion Molecule (NRCAM))

Autre désignation: NrCAM

Sujet:

Synonyms: Neuronal cell adhesion molecule, Bravo, hBravo, KIAA0343, MGC138845, MGC138846, Neuronal surface protein Bravo, Ng CAM related, Ng-CAM-related, NgCAM related cell adhesion molecule, NgCAM-related cell adhesion molecule, Nr CAM, Nr-CAM

Background: Neuronal cell adhesion molecule (NrCAM) is a cell surface protein of the immunoglobulin (Ig) superfamily. NrCAM (also known as Bravo) contains six Ig domains, five fibronectin repeats, a transmembrane region and an intracellular domain. NrCAM is expressed in brain, spinal cord, peripheral nervous system and pancreas. In the spinal cord, NrCAM acts as a ligand for axonin-1 to guide commissural axons across the floor plate. NrCAM also acts as a ligand for F3 to control actin-dependent growth cone motility. NrCAM interacts with neurofascin and may facilitate the clustering of the cystoskeletal protein ankyrin G and the voltage-dependent sodium channel proteins at the node of Ranvier. NrCAM expression may play a role in the severity of certain types of tumors. NrCAM is overexpressed in high-grade astrocytomas, gliomas and glioblastoma tumor tissues. Anti-NrCam is ideal for research in Cancer and Neuroscience. In the pancreas, NrCAM expression is upregulated in intraductal hyperplasia. Antisense NrCAM reduces the tumorigenic properties of human glioblastoma cells in vitro and slowed tumor growth in vivo. The gene encoding human NrCAM maps to chromosome 7q31.1-q31.2.

Gene Name: NrCAM

ID gène: 319504

NCBI Accession: NP_001139503

UniProt: Q810U4

Pathways: Regulation of Cell Size